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Vitamin C (CAS 50-81-7) is a water-soluble vitamin studied extensively in biomedical contexts for its potential anticancer and antiviral activities Mechanistically vitamin C exerts antiproliferative effects on tumor cells and promotes apoptosis as demonstrated in murine colon cancer (CT26) cells At concentrations of 100-200 g/ml vitamin C inhibited proliferation significantly higher levels (200-1000 g/ml) induced apoptosis dose-dependently In vivo studies showed vitamin C treatment reduced tumor volume markedly in CT26 and 4T1 tumor-bearing BALB/c mouse models These findings highlight vitamin C s utility in cancer research as a therapeutic adjunct and investigational agent
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Vitamin K2 (Menaquinone) is an important fat-soluble vitamin that plays critical roles in protecting heart and brain and building strong bones It also plays an important role in cancer protection
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Synthetic/ basal media used currently contain amino acids carbohydrates vitamins and salts. Eagle minimum essential medium (MEM) is a modified version of BME (basal medium Eagle) which contains increased amounts of each amino acid. Addition of water soluble vitamins such as inositol to various culture facilitates the hatching of hamster and rabbit blastocysts. Vitamins also influence the metabolism of glucose in sheep and mouse embryos.
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Also available in 10 mg 25 mg 50 mg 100 mg 200 mg and bulk. Please contact Fisher for quotes. (alpha)-Tocopherol phosphate (alpha-Tocopherol phosphate) is an antioxidant that scavenges UVA1-induced reactive oxygen species (ROS) and protects against long-wave UVA1-induced cell death. alpha-Tocopherol phosphate disodium impedes endothelial progenitor cell apoptosis enhances endothelial progenitor cell migration under high glucose/low oxygen conditions and promotes angiogenesis. (alpha)-Tocopherol phosphate disodium (Vitamin E phosphate disodium) prevents apoptosis enhances migration of endothelial progenitor cells under high glucose/low oxygen conditions and promotes angiogenesis. purity: 99%
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SCH900776 S-isomer is a small-molecule inhibitor targeting checkpoint kinase 1 (Chk1) It is designed to inhibit Chk1 kinase activity thereby interfering with DNA damage-induced checkpoint responses and disrupting S-phase cell-cycle arrest SCH900776 S-isomer exerts its biological activity primarily through selective inhibition of Chk1 kinase (IC50 3 nM) with substantially weaker inhibition toward Chk2 (IC50 1500 nM) and CDK2 (IC50 160 nM) In cellular assays treatment with SCH900776 S-isomer mimics the genetic depletion of CHK1 by RNA interference Based on these pharmacological properties SCH900776 S-isomer holds research potential in oncology particularly in combination with DNA-damaging chemotherapeutics to study enhanced cytotoxicity and altered cell-cycle progression in tumor and leukemia cell lines
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